The TG Supramolecular and Medicinal Chemistry Research Group is based in the School of Chemistry, Trinity College Dublin and is at the cutting edge of research into supramolecular structures, sensor design and materials development. The principal investigator is Professor Thorfinnur Gunnlaugsson.
The TG Group is housed in the Trinity Biomedical Sciences Institute (TBSI), as part of the School of Chemistry. The School is divided between several institutes on and near the main campus, such as the Chemistry Building, the Sami Nasr Institute of Advanced Materials (SNIAM), the Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) and TBSI (Map).
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Many congratulations to Elena De Calatrava Pérez, who successfully defended her PhD
thesis titled “The Synthesis, Photophysical and Biological Evaluation of Glycosylated
Naphthalimides for Medicinal and Material Applications”. Elena was a joint PhD student of Thorri and his close collaborator Prof. Eoin Scanlan; her work was examined by Prof. John Callan, The Norbrook Chair in Pharmaceutical Science, from the School of Pharmacy & Pharmaceutical Science at Ulster University. and prof. Mike Southern as the internal examiner. It was a great occasion, which was followed by a lunch in one of our
favourite restaurants, Pig’s Ear, and a small celebration in TBSI. Elena is currently working as a postdoctoral fellow in St. James’s Hospital here in Dublin.
Elena’s PhD was funded by the SFI and focused on the development of novel glycosylated naphthalimide structures and their application in both medicinal and material chemistry. A large part of her work focused on the use of high-resolution imaging, which was carried out in collaboration with several members of the TG group as well as in close collaboration with Dr Gavin McManus from the School of Biochemistry and Immunology here at TCD. Some of her work has been published in the RSC journals Chem Commun and most recently in the OBC. We all at TG group wish Dr De Calatrava Pérez best of luck for her future!
Isabel has returned to the group following a three month internship at Alkermes Biopharmaceutical. During the internship Isabel worked as part of the R&D Formulations department, developing formulations for new oral dose drug substances, which allowed her to get experience in early stage formulation development through to scale-up, as well as investigating the potential for PAT (Process Analytical Technology), in the form of various spectroscopic techniques, with a view to inline process monitoring. This opportunity was made possible due to a collaboration with Tarek Zeidan (Alkermes, Waltham) on Isabel’s PhD project over the last three years. This experience will greatly benefit Isabel as well as the wider Gunnlaugsson group.
It has been a busy Monday for the TG group! Today, in fact, Adam and June went to attend Macrocyclic and Supramolecular Chemistry (MASC) meeting for 2018 at Lancaster University, where they had a chance to take part in the poster sessions where they summarized their works on Aggregation Induced Emission and Naphtalimides coordination structures, respectively.
At the same time, in Belfast, Bruno and Emanuele attended the Inorganic Ireland Symposium at Queen’s University in Belfast, where they also presented the poster on their joint work on BTA ligand-sensitized Lanthanide cyclen complexes.
Bruno (left) and Emanuele (right) during the poster session at Queen’s University
Way to go!
Our first year student Deirdre co-facilitated RSC’s Spectroscopy In A Suitcase workshop to the 6th year Chemistry class at St. Paul’s College today in Raheny. The students solved a Murder Mystery while being introduced to different analytical tools including mass spectrometry, IR and UV-Vis spectroscopy.
Many congratulations to Hannah, Amy and Chris (http://hawesgroup.wordpress.com) on their paper that has been accepted for publication in Dalton Transactions, entitled: “Exploring the reversible host–guest chemistry of a crystalline octanuclear Ag(I) metallosupramolecular macrocycle formed from a simple pyrazinylpyridine ligand”. This exciting work was developed by Hannah and Chris in collaboration with Brendan Twamley, Kevin Byrne and Wolfgang Schmitt (Dalton Trans. DOI:10.1039/c8dt04583f). This highly novel work focusses on the use of some 2-(2′-pyrazinyl)pyridine based building blocks, that we have been developing in the TG laboratory and their coordination chemistry with Cu(II) and Ag(I) ions. This has lead to the discovery of metallosupramolecular architectures that have some surprising complexity; some of these systems (the metallosupramolecular macrocycles) being employed in this Dalton contribution for carrying out solvent exchange in a single-crystal-to-single-crystal transformation as demonstrated in the figure below.
Well done and special congratulations for Hannah for her first “Dalton on Dalton” paper!
Many congratulations to June, now in her second PhD year, who has had her paper with Chris Hawes (former member of the TG Group and now and independent lecturer at the School of Chemical and Physical Sciences, Keele University, UK, named “Crystallographic studies of 2-picolyl substituted naphthalene diimide and bis-phthalimide ligands and their supramolecular coordination chemistry”, accepted for publication in CrystEngComm (DOI: 10.1039/C8CE01756E). This work is another excellent outcome of a very fruitful collaboration between the group and Chris, based on exploring the supramolecular application of naphthalene-based building blocks with various d-metal ions, featuring extended analysis of the various complexes formed by using single crystal structure analysis, but Chris was instrumental (as well as Brendan Twamley) in training several members of the TG group in carrying out their own X-ray analysis.
Many congratulations to Sachi, Bruno and David, who have had their paper on the generation of highly luminescent functional solid-state material, “Self-assembled bright luminescent hierarchical materials from a tripodal benzoate antenna and heptadentate Eu(III) and Tb(III) cyclen complexes” accepted in Frontiers of Chemical Science and Engineering (Front. Chem. Sci. Eng. 2019, DOI:10.1007/s11705-018-1762-3). This work, achieved in collaboration with the Prof. Wolfgang Schmitt research group here at TCD covers the use of self-assembly between cyclen-based lanthanide (Europium and Terbium) complexes and a tripodal ligand which yields a luminescent amorphous material (red and green respectively, as shown below) that can be used for the sensing of solvents such as MeOH, CH3CN and THF.