New paper accepted in Chemical Science on a novel lanthanide-based white-light emitting system

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Varying the colour of the emission by altering the molar fraction of europium in the system (𝛘Eu)

Congratulations to Oxana Kotova, Steve Comby and Christophe Lincheneau on their paper entitled “White-light emission from discrete heterometallic lanthanide-directed self-assembled complexes in solution” which has been accepted into the RSC journal Chemical Science. In this work, the newly designed multidentate ligand tdt was used, which provides three individual tridentate binding sites for lanthanide (Ln) ions. White-light emission was successfully achieved by carefully tuning (i) the molar ratio of Eu(III) and Tb(III) within the assembly and thus the relative intensity of the red and green emission, (ii) the excitation wavelength, as the tdt ligand consists of two different chromophores, and (iii) the ligand concentration, which greatly affects the intensity of the blue emission within the overall self-assembled complexes. We envisage that this system can be further developed and find its application as white-light emitting material or as a ratiometric sensor.

New paper in Organic Letters on anion mediated synthesis of 3-amino-[1,2,4]-triazolo pyridines from our group

Many congratulations to present and former members of our group Komala, Anna, Devis, Jon, Miguel and Salvador for their recent publication, Supramolecular Anion Recognition Mediates One-Pot Synthesis of 3-Amino-[1,2,4]-triazolo Pyridines from Thiosemicarbazides, in Organic Letters!. This work was done through a collaboration of Prof. Gunnlaugsson and Prof. Eoin Scanlan and showed how supramolecular interactions with F (as tetrabutylammonium fluoride, TBAF) of a series of thiosemicarbazides could lead to the formation of 3-amino-[1,2,4]-triazolo pyridines. The synthesis of these heterocycles was obtained in a one-pot reaction from variously substituted hydrazine pyridine and isothiocyanates in the presence of TBAF.

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Crystal structures of thiosemicarbazides and 3-amino-[1,2,4]-triazolo pyridines.

New Paper for June, Chris and Amy

Congratulations to June Lovitt, Chris Hawes and Amy Lynes on their new paper in Inorganic Chemistry Frontiers, entitled ‘Coordination chemistry of N-picolyl-1,8-naphthalimides: colourful low molecular weight metallo-gelators and unique chelation behaviours‘. June has spent the last six months as a research student in our lab, and has now returned to the University of Southampton to complete her studies. We all hope to see June again soon, but in the meantime we would like to wish her best of luck in all her future endeavours!

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Transparant low molecular weight metallogels such as the one pictured (green) were formed from N-picolyl-1,8-naphthalimides

A new paper on monitoring the onset of bacterial infection using lanthanide luminescent probes within hydrogels accepted for publication in JACS

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The europium-based luminescence is only quenched when urease enzymes break down urea in the solution

Many congratulations to Esther, Sam and Sandra who had their paper “Luminescent Lanthanide Cyclen-Based Enzymatic Assay Capable of Diagnosing the Onset of Catheter-Associated Urinary Tract Infections Both in Solution and within Polymeric Hydrogels” accepted in the Journal of the American Chemical Society. The work focuses on using delayed 
luminescence Eu(III)-based pH-responsive probes to monitor the activity of urease, which hydrolyses urea in
 aqueous solution upon onset of bacterial infection.
 This system can be incorporated into soft polymeric materials such as hydrogels. The work was carried out in collaboration with Prof. Clive Williams of the School of Biochemistry and Immunology in TCD and Prof. Colin McCoy from the School of Pharmacy, Queen’s University of Belfast.

CASE 2015 on the Cover of Supramolecular Chemistry

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This month’s cover of Supramolecular Chemistry

This month’s issue of the Taylor & Francis journal Supramolecular Chemistry features a review on CASE 2015 by Robert Elmes, with a picture from the conference on the cover. CASE 2015  (Catalysis and Sensing for our Environment) was part-hosted in Trinity College Dublin, and organised by Thorri, along with Aisling Hume (TCD), Donal O’Shea (RCSI), and Robert Elmes (Maynooth).

Cover feature for Elena’s work in Chemical Communications

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The inside front cover designed by Elena De Calatrava-Pérez and Amparo Mérida-Navas

Many congratulation to Elena De Calatrava-Pérez on her article in Chemical Communications: Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated ‘pro-probes’ (Chem. Commun., 2016, 52, 13086-13089). The work has been featured on the cover of the journal, which was designed by Elena and her sister-in-law Amparo Mérida-Navas, a trained graphic designer. The work describes the development of fluorescent glycosylated 4-amino-1,8-naphthalimide derivatives as ‘pro-probes’ that are taken up into cancer cells upon being selectively hydrolysed in situ by glycosidase enzymes. Elena is a joint PhD student between Thorri and Prof. Eoin Scanlan in the School of Chemistry here at TCD (both based in TBSI) and the work was carried out in collaboration with Prof. Clive Williams from the School of Biochemistry and Immunology (TBSI).