Congratulations to Laura (now at Pfizer), Sam, Steve and Oxana on their new communication published in ChemPhysChem. In this work, invited to a special issue on Molecular Logic, AuNPs were described that were functionalised with Eu(III) and Tb(III) cyclen complexes which were able to function as molecular logic gate mimics (MLGMs). Two MLGMs were reported operating using pH and organic molecule inputs, respectively, which were able to mimic half-subtractor, transfer and XOR logic functions.
Logic and Molecular logic have important history in Ireland, with George Boole developing his ideas in UCC (formerly Queen’s College Cork) and the early ideas of PET sensors as MLGMs being introduced by Prof. A.P. de Silva in Queen’s University Belfast. The TG Group has described a number of MLGMs over the years, most recently in materials systems such as our organogel-based system reported in Chem. Commun. last year. Our paper in ChemPhysChem is a further demonstration of the use of materials-supported Ln(III) luminescence, this time on AuNP surfaces and the power of logical analysis as an approach to supramolecular and sensing chemistry.
ChemPhysChem is a ChemPub Soc Europe journal, a consortium of 16 continental European chemical societies and published in collaboration with Wiley-VCH, and we are happy to have contributed to high impact European science.
On Tuesday 30th May, 3rd year students Anna Aletti, Sandra Estalayo, Dermot Gillen and Amy Lynes participated in the annual Third Year Talks, which took place at University College Dublin as part of the Dublin Chemistry graduate program. The day gave them the opportunity to present their work and achievements so far in their PhDs to an audience of their peers and academics. The day was supported by Lilly and brought together PhD students from UCD and DIT for a full day featuring 52 talks, spanning all disciplines of chemistry.
Anna and Dermot presented their work on anion receptors and anion-directed self-assembly; Amy talked about the synthesis of BTA gels and soft materials; while Sandra spoke about the design of Ru(II) polypyridyl complexes for biological applications such as photodynamic therapy (PDT).
Congratulations to all who participated. Well done Anna, Dermot, Amy and Sandra for another year of excellent talks from the TG group!
Structure of the tetrameric [Zn4(L)4]8+ cation investigated in the work.
Congratulations to Dawn, Chris, Bjø
rn and Joe for their recent paper in Dalton Transactions titled “A folded [2 × 2] metallo-supramolecular grid from a bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand
“. In this work, a new flexible bis-tridentate donor ligand containing 1,2,3-triazolyl-picolinamide (tzpa
) binding sites was developed, which contained structural elements from two of the group favorites 2,6-dipicolinamide (dpa
) and 2,6-bis-(1,2,3-triazolyl)pyridine (btp
). The new ligand was then used in the formation of a tetranuclear grid with Zn(II) or Fe(II) ions, which was probed with X-ray diffraction, NMR, UV-Visible spectroscopy and mass spectrometry. It also involved a productive collaboration with Dr Manuel Reuther and Dr John O’Brien from the NMR Spectroscopy Facility
in TCD, who provided help in understanding the solution behavior of the material using the T1
spin-lattice relaxation parameter in 1
H NMR spectroscopy.
After the ceremony, with several members of the group
The group gathers for a photo at dinner
Wedding Day wishes sent from Ireland!
Many congratulations to Sam and Anna on the occasion of their wedding! The ceremony was held in Anna’s home country of Italy, and several past and present members of the group were lucky enough to celebrate the happy occasion with the newly married couple. We wish you the very best in your life together!
Helen with Barry from the Evans group
Congratulations to Helen Burke, who joined the group in 2012 as an IRCSET postgraduate scholar, and officially graduated as a Doctor of Philosophy in Chemistry earlier today. Helen carried out her research on ‘Synthetic Approaches Towards Thioester-Mediated Bioconjugation and Lanthanide-Based Glycoconjugate Probes’ jointly with Eoin Scanlan, producing several publications, the most recent of which appeared in Organic and Biomolecular Chemistry (DOI: 10.1039/C6OB01712F).
Since submitting her thesis, Helen has started work in industry in England. Everyone in the TG group would like to say farewell to Helen and we all wish her the best of luck in her future endeavours!
Örn Almarsson, Head of Formulation of Moderna Therapeutics in Cambridge, Massachusetts, gave a lecture about his work titled “Messenger RNA: A Novel Therapeutic Approach”, today. Moderna Therapeutics have demonstrated the possibilities offered by mRNA-based treatments, establishing partnerships with Merck, receiving awards for their research achievements and raising over $1.1 billion in equity financing.
Örn was invited to speak to TBSI by Thorri, of whom he is a longtime friend. It was a pleasure to have him talk about his work and provide a unique insight into the world of cutting-edge industry research.
Thorri introduces Orn’s Work
Orn answers questions from the audience
Group Photo: Hannah (three rows back, 5th from right) and Eoin (4th row back, 5th from left)
Eoin Mc Carney and Hannah Dalton recently attended the 16th BCA/CCG Intensive Teaching School in X-ray Structure Analysis. The week-long residential course was held from Saturday 25th March until Sunday 2nd April at Trevelyan College in Durham University. Congratulations to Hannah and Eoin for completing the course!