The group have had their article titled “Tracking the cellular uptake and phototoxicity of Ru(II)-polypyridyl-1,8-naphthalimide Tröger’s base conjugates” accepted for publication in the RSC journal RSC Chemical Biology, in collaboration with the groups of Prof. Robert Elmes, Chemistry, Maynooth University, and Prof. Clive Williams, School of Biochemistry and Immunology, TCD, and with researchers from the Université Libre de Bruxelles. The article is the outcome of a long-standing collaboration between the these research groups within the area of developing luminescent Ru(II) polypyridyl complexes as cellular targeting probes and as photo-activated cancer therapeutics. The work described here is centered on the latter, as there are use of highly potent bis-Ru(II) complexes formed by using the highly-versatile naphthalimide Tröger base building platform, under low energy light dose. The work was supported by the SFI and the IRC and is published as an open access and can be downloaded here: https://pubs.rsc.org/en/content/articlelanding/2024/cb/d3cb00206c
Gunnlaugsson Group, Trinity College Dublin 