Elena de Calatrava Pérez presented her work on “The Development of Glyconaphthalimides for Medicinal Applications” at the young investigator session of the 2017 meeting of the Royal Society of Chemistry carbohydrate group. Elena conducts this work as part of a close collaboration between Thorri and Prof. Eoin Scanlan. The Meeting featured an exciting array of both industry and academic talks, and was held in TBSI over the 7th and 8th of September.
Congratulations to Sachi, who successfully defended his PhD thesis today, entitled “Luminescent Self-assembled Supramolecular Polymers and Microspheres Based on Benzene-1,3,5-tricarboxamide (BTA) Derivatives”.
After the viva examination, Sachi and his examiner David K. Smith joined the rest of the TG group for a celebratory reception in the Trinity Biomedical Sciences Institute.
Many congratulations to present and former members of our group Komala, Anna, Devis, Jon, Miguel and Salvador for their recent publication, Supramolecular Anion Recognition Mediates One-Pot Synthesis of 3-Amino-[1,2,4]-triazolo Pyridines from Thiosemicarbazides, in Organic Letters!. This work was done through a collaboration of Prof. Gunnlaugsson and Prof. Eoin Scanlan and showed how supramolecular interactions with F– (as tetrabutylammonium fluoride, TBAF) of a series of thiosemicarbazides could lead to the formation of 3-amino-[1,2,4]-triazolo pyridines. The synthesis of these heterocycles was obtained in a one-pot reaction from variously substituted hydrazine pyridine and isothiocyanates in the presence of TBAF.
Helen Burke, who joined the group in 2012 as an IRCSET postgraduate scholar, defended her PhD thesis, entitled ‘Synthetic Approaches Towards Thioester-Mediated Bioconjugation and Lanthanide-Based Glycoconjugate Probes’, today.
The four year research project was conducted jointly with Eoin Scanlon as part of a fruitful collaboration which has seen her work appear in several publications, most recently in Organic and Biomolecular Chemistry. Helen’s examiners, Trinity’s Joanna McGouran and Tony D. James from the University of Bath, joined the research group for a reception in the Trinity Biomedical Sciences Institute afterwards to celebrate.
Many congratulation to Elena De Calatrava-Pérez on her article in Chemical Communications: Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated ‘pro-probes’ (Chem. Commun., 2016, 52, 13086-13089). The work has been featured on the cover of the journal, which was designed by Elena and her sister-in-law Amparo Mérida-Navas, a trained graphic designer. The work describes the development of fluorescent glycosylated 4-amino-1,8-naphthalimide derivatives as ‘pro-probes’ that are taken up into cancer cells upon being selectively hydrolysed in situ by glycosidase enzymes. Elena is a joint PhD student between Thorri and Prof. Eoin Scanlan in the School of Chemistry here at TCD (both based in TBSI) and the work was carried out in collaboration with Prof. Clive Williams from the School of Biochemistry and Immunology (TBSI).
Many congratulations to Helen and Elena who are joint PhD students with Professor Eoin M. Scanlan on their papers that have been accepted for publication in the RSC journals Organic Biomolecular Chemistry and Chemical Communications, respectively. A great collaboration between the TBSI based groups, involving several other researchers from the School of Chemistry as well as the School of Biochemistry and Immunology:
“Glycosylated Lanthanide Cyclen Complexes as Luminescent Probes for Monitoring Glycosidase Enzyme Activity”, Helen M. Burke, Thorfinnur Gunnlaugsson and Eoin M. Scanlan, Org. Biomol. Chem., 2016, 14, 9133-9145. DOI: 10.1039/C6OB01712F
“Glycosidase Activated Release of Fluorescent 1,8-Naphthalimide Probes for Tumor Cell Imaging from Glycosylated ‘Pro-probes’”, Elena Calatrava-Pérez, Sandra A. Bright, Stefan Achermann, Claire Moylan, Mathias O. Senge, Emma B. Veale, D. Clive Williams, Thorfinnur Gunnlaugsson and Eoin M. Scanlan, Chem. Commun. 2016, 52, In Press. DOI: 10.1039/C6CC06451E
The Royal Society of Chemistry held its annual Organic Division Ireland Regional Meeting in the Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, on the 19th of May 2016. The meeting was organised by Prof. Eoin Scanlan from the School of Chemistry (TCD), and featured contributions from several Irish Universities. These included Maynooth University, University College Dublin, University College Cork, Trinity College Dublin, NUI Galway and the Royal College of Surgeons in Ireland.
In addition to featuring lectures by Irish researchers, Professor Véronique Gouverneur (Oxford University) presented her 2016 Tilden Prize Lecture. The meeting was attended by a large crowd of researchers with over 30 posters being presented at a dedicated poster session.
Anna Aletti from the TG group was awarded a prize for her poster about the anion studies on our btp-based catenane, recently accepted in Angewandte Chemie. Congratulations to Anna and also to Fiona O’Donovan (UCC) for winning the poster prizes.
A great day that showcased some of the most exciting chemistry research being carried out in Ireland at the moment.
More info can be found at: