New paper on DNA-targeting phototherapeutic drugs published in Chem. Eur. J.

Congratulations to Fergus and Bjørn on their recent paper in Chemistry a European Journal titled Inosine can increase DNA’s susceptibility to photo-oxidation by a Ru(II) complex due to structural change in the minor groove. Key to the development of DNA-targeting phototherapeutic drugs is determining the interplay between the photoactivity of the drug and its binding preference for a target sequence. In this work, the photoactivity of Λ-[Ru(TAP)2(dppz)]2+ and its binding to oligonucleotides was studied, showing enhanced photo-oxidation when guanine is substituted with inosine, in spite of inosine being less easily oxidised. The work has been performed in collaboration with Prof. Susan Quinn of University College Dublin, Páraic Keane and Prof. Christine Cardin of the University of Reading, Prof. John Kelly from Trinity College Dublin and groups at the Diamond Light Source and Rutherford Appleton Laboratories in England.


Structural features of the interaction of the Ru(II) complex with two different DNA sequences.